Following the announcement of the presidential election results, Barack Obama (Trey Parker) and John McCain (Matt Stone) address their supporters on nationwide TV as the South Park townspeople gather to watch. Randy and the other Obama supporters (including the Marshes and Broflovskis, except for Ike, who supported McCain) celebrate drunkenly in the streets, cheering and screaming his name as well as his campaign slogans, while McCain supporters (including the Stotches, Mr. Garrison, and Mr. Mackey) sit despondently inside, fearing that it is the end of the world. Ike attempts suicide by jumping out a first-story window; he survives but appears to be badly injured, and Stan and Kyle try to take him to the hospital.
Stan and Kyle search through the partying crowd to find anyone who can drive Ike to the hospital, without success. Randy, believing that Obama’s win means he will be financially secure forever, insults and beats up his boss (also an Obama supporter). Other revelers tip over Officer Barbrady’s police car when he tries to restore order. Meanwhile, Cartman has taken advantage of the chaos to steal TV sets from people’s houses and is now selling them from a cart strapped to his Big Wheel.
Stan and Kyle find the Stotches building an “ark” to hold some of the McCain supporters, thinking that Obama’s win will bring about the end of civilization. The boys’ plea for help leads to a brawl among the adults, so they head for the hospital on foot. The emergency room is packed with patients who have either partied too hard or tried to kill themselves to the point that the hospital nurse can determine what has happened to Ike by simply asking which candidate he supported. Randy is found here as well, trying to still party while singing Barry Manilow’s “Mandy” (replacing “Oh, Mandy” with “Obama”).
Meanwhile, it is revealed in a side story that Obama and McCain were actually jewel thieves and staged the entire election so that one of them could gain access to the Oval Office. This was to access a tunnel that would lead to the Smithsonian Museum, where they would steal the Hope Diamond. They were able to accomplish the mission with the help of Michelle Obama, a computer hacker who had also faked her marriage with Obama to fool the press, and Sarah Palin, who is actually highly intelligent and British. Once the plan was complete, a private jet that contained dummies of the criminals was blown up near the hospital in South Park. This gave Ike, who was working with McCain and Obama and had faked his earlier injury, a chance to alter hospital records to declare everyone involved legally dead.
The next day, as the gang is about to leave the country, Obama decides that he does not want to go with them. Instead, he and Michelle decide to stay behind to “give this President thing a try.”
At the end of the episode, the McCain supporters emerge from their “ark” to find that society has not collapsed overnight. They admit that they may have overreacted to the election results and decide to give President Obama a chance. As for Randy, he wakes up on his couch hungover and is surprised to learn that not only has he been fired, his TV was stolen (by Cartman). He then declares that it is all Obama’s fault and that he should have voted for McCain.
The episode opens with a monologue by Craig, explaining what had happened in the previous episode. Craig’s monologue is actually a narration of his journal, which he is writing in the Andes mountains. He, the other boys and the pilots are stranded without gas at a false rendezvous point. They look for help in the jungle, but find only a “lost giant world,” filled with humongous fruits. The two pilots are killed by baby Guinea bee larvae; the boys flee.
Craig and the boys discover a temple, inside of which are carvings depicting a prophecy that details all of the events of the previous episode. They learn from this that the Peruvian flute bands kept the murderous guinea pigs within the jungle. Craig is featured in the final carving. In spite of the intrigue of the carving, Craig refuses to do any more investigating and begins walking back through the jungle. The other boys follow him, complaining of boredom.
Interspersed throughout this story are various flashes in Colorado with Randy, Sharon and Shelly hiding from giant guinea pig monsters (all of which are portrayed by real live-action guinea pigs wearing costumes). They hide at home, in a damaged bus, on the roof of a Best Buy, a grocery store, and an Outback Steakhouse. Randy does not stop filming the entire time, and uses unnecessarily shaky camera work, as well as constant zooms and heavy breathing to convey just how “startled” he is by the whole ordeal. The other townspeople, especially Sharon, begin to grow very annoyed by his obsessive taping of the event, which he describes “will be a very important family relic, years from now.” Also, the townsfolk discover that the guinea pigs take on various other permutations, including guinea rabbits, guinea bees, guinea mice, and guinea-saurus rexes, all of which supposedly originate from the aforementioned “giant world.”
Meanwhile, the head of Homeland Security travels to Machu Picchu to finalize his plan for world domination. He accidentally runs into the boys and orders his guards to kill them, claiming they are a Peruvian flute band (which in the previous episode were prosecuted and ordered into Guantanamo Bay). Stan explains that they aren’t and that the bands are the only forces which could stop the guinea pigs.
The director of Homeland Security snaps, revealing his plan to everyone. One of the guards shoots him, but that doesn’t stop the director, who then reveals his true form, that of a “guinea pirate” (a live-action guinea pig in a pirate outfit). Craig simply steps away from the scene as he does not want to interfere. He accidentally steps on a stone tile, activating some sort of magical ritual in which lasers shoot out of his eyes and paralyze the Guinea pirate. Craig seems unfazed by the occurrence, stating, “Okay, now there are sparks shooting out of my eyes…”
The episode ends with a second monologue by Craig, telling the aftermath of the incident as a pan flute cover of Gary Numan’s “Cars” plays in the background. The U.S. government releases all the pan flute bands, who then drove the guinea pigs away back to the jungle. Craig concludes that you never know what life has in store for you, and also that he will never trust anyone who asks him for his birthday money ever again. He is shown shutting his front door on the boys, who have come to his house dressed as a Mariachi band, supposedly beginning the cycle over again.
It is also revealed at this time that Randy forgot to put a tape in his camera, therefore making his entire effort to tape the ordeal pointless.
Meanwhile back at the office of Homeland Security, the new Director is informed that the guinea pirate has broken out of jail and has begun to attack the city. The ending sequence shows the escaped giant guinea pirate roaming through the streets of Washington D.C. in his black-and-white prison uniform.
Seeing all the Peruvian pan flute bands that have become popular recently, and the money they can make daily by selling CDs, Stan convinces the other boys to start their own pan flute band. They convince their classmate Craig to invest his $100.00 USD birthday money as venture capital. The plan backfires when the head of the U.S. Department of Homeland Security cracks down on all Peruvian flute bands, rounding them up and imprisoning them in Miami, with the boys arrested in the process. The boys attempt to convince their captors that they are American citizens, but the DHS only agrees to release the boys if they agree to go on a mission to overthrow the country of Peru, in order to stop the pandemic of Peruvian flute bands at its source. As the boys prepare for their mission, Peruvian musicians still interned in the camp warn guards that their captivity will unleash the “Furry Death”.
Meanwhile, Stan’s father, Randy Marsh, raises the ire of his family by videotaping every mundane household activity with his new camcorder. His camera documents the rampage of giant guinea pigs through town. At the episode’s conclusion, the boys are headed to Peru as the country begins to be overrun by guinea pigs. It is revealed that the head of Homeland Security is a demonic lifeform facilitating the eradication of pan flute bands and the rise of the guinea pigs, and that he sent the boys to Peru because the only one with the power to stop him is Craig.
The episode begins with Cartman mocking Wendy’s presentation on breast cancer awareness. Mr. Garrison does little to stop him and after class, Wendy announces she is going to fight Cartman after school. Cartman tries to call off the fight with apologies, bribery, and desperate claims. When Wendy tells him she will “shove your ass down your throat and make you eat your underwear!” he painfully chokes down his underwear in an attempt to appease her, but this only disgusts and angers her.
Cartman tries to convince Stan to talk Wendy out of it, but Stan does not believe he can do anything stop her. Desperate to avoid the fight, Cartman defecates on Mr. Garrison’s desk, earning him a detention and Butters, Craig and Jimmy tell him there are rumors that he got detention to avoid the fight, which Wendy has rescheduled for the following morning.
Later, Cartman has his mother convince Wendy’s parents not to let her fight, but continues to taunt her, as do the other students. When Cartman continues to taunt her in class, she nearly fights him but is called to Principal Victoria’s office. Much to Wendy’s surprise, Principal Victoria explains she is a breast cancer survivor and implies that Wendy should fight Cartman the same way Principal Victoria fought her cancer, telling her to; “beat that fat lump”.
Wendy finally meets Cartman on the playground and fights with him. Cartman puts up a fairly good fight but is heavily beaten up by Wendy and loses. He declares that his friends will not find him cool any more, but they tell him they always hated him and always will, stating that they cannot possibly think any lower of him. Cartman takes this to mean that they are pretending to make him feel better, and he walks away happy.